Digestive Enzymes After Gallbladder Removal

Have you been thinking about taking digestive enzymes after gallbladder removal surgery to deal with your lingering symptoms? Not sure if they will really help? Here, Ana, a nutritional scientist, breaks down the evidence for you so you can make an informed choice!

Did you know that the rates of digestion-related disorders are sky-high?

Even if you didn’t, it probably doesn’t come as a surprise when you hear it. After all, a sedentary and unhealthy lifestyle is a common picture of modern society.

I mean, there is a reason the term “Western diet” is always used in a negative context, but that’s the reality.  Our diet — rich in fats and processed foods — leads to all kinds of health complications.  Why should digestive complications be any exception?

And among the most prevalent digestion-related complications is gallbladder disease.

Gallbladder Disease – Statistics and Causes

Epidemiological studies from the early 2010s estimated that gallbladder disease affects between 10-15% of American adults (which is around 20 to 25 million) at some point in their lives.  

What’s worse, these rates seem to show a constant increase year after year, with more than a 20% increase over the last three decades.

Standard treatment for gallbladder disease is surgical removal of the organ, medically known as a “cholecystectomy”.  

The leading cause for gallbladder removal surgery is gallstones – small compounds that are formed inside the gallbladder when bile crystallizes.  However, other medical conditions may require it as well, such as:

Although the number of performed gallbladder removal operations is high (800,000 each year), the surgery is not without risks. 

Upsettingly, around 50% of people don’t see improvement in their digestive symptoms after their surgery.  Some even develop new digestive symptoms they hadn’t struggled with before their operation because the operation itself somehow provoked them!   

Luckily, there is some good news.  If you are one of the roughly 400,000 people each year who continue (or start) to struggle with chronic digestive issues after having your gallbladder removed, there are natural ways that can help you ease them!  

Here, I will give you an overview of the possible digestive complications of gallbladder removal surgery and what you can do to reduce them!

What Does Your Gallbladder Do?

Gallbladder Diagram
Source: https://upload.wikimedia.org

Your gallbladder is a pear-shaped organ located beneath your liver.  Its main role is to store and concentrate bile — a yellow, brownish, or olive-green liquid that helps you digest fats.

Bile is produced by your liver (not your gallbladder!) and flows through small canals, through a channel called “the common bile duct” and into your gallbladder for storage.  

When the food enters your small intestine, your body secretes a hormone (cholecystokinin), which sends a message to the gallbladder to contract and release the bile.  The common bile duct releases the bile into your small intestine to help your body break down all the fat in your meal.

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What are the Side Effects of Not Having a Gallbladder?


First, I have to point out that gallbladder surgery isn’t without its benefits for many people!  The benefits of gallbladder surgery are:

  • relieving severe abdominal pain from gallbladder disease or gallstones
  • resolving serious gallbladder infections before they can spread
  • preventing new gallstones in those who’ve had multiple gallbladder attacks and, in most cases, stopping the gallstones come back.

However, as with every surgery, gallbladder removal itself poses certain risks.  During gallbladder surgery:

  • an injury may occur in the bile duct
  • whole or partial gallstones may remain (if part of the organ remains, as well)  
  • bile may start leaking in other organs  

Unfortunately, for some individuals, gallbladder surgery is not the right treatment option at all and their gallbladder symptoms simply continue to persist after the operation.  For others, the surgery triggers new digestive and abdominal symptoms.  These potentially long-term side effects of gallbladder removal surgery are commonly collectively referred to as “post-cholecystectomy syndrome”.

The exact symptoms of the post-cholecystectomy syndrome can include:

  • upset stomach
  • nausea
  • vomiting
  • gas
  • bloating
  • diarrhea
  • persistent pain in the upper right abdomen
  • inflammation of the stomach lining (gastritis)
  • indigestion (dyspepsia)
  • yellow discoloration of the skin (jaundice)
  • reflux of bile acids

Let’s now look more closely into the components of the post-cholecystectomy syndrome and what may cause them!

Diarrhea, Constipation, and Flatulence

Diarrhea, constipation, and flatulence often occur as a result of poor digestion, regardless of whether or not you’ve undergone gallbladder removal surgery.  

After gallbladder surgery, poor digestion is likely driven by a poor balance of bile acids in your digestive tract.

Bile acids are responsible for emulsifying, solubilizing, and carrying the fatty compounds and, thereby, easing their digestion.

Since the gallbladder normally stores and concentrates bile acids and releases them when you eat, without a gallbladder, you can become “deficient” in bile acids after your meals.

If this occurs, there is not enough bile to allow you to properly digest the fat in your food, which can lead to fatty, loose stools (i.e. diarrhea).  

In most cases, diarrhea doesn’t last longer than one week after surgery, but it may last several months, especially if dietary restrictions to reduce your fat intake aren’t followed.  

While diarrhea is more common following gallbladder removal, constipation may occur, as well, as a side effect of medications used to manage post-surgery pain.

Gastritis and Biliary Reflux

Gastritis describes a condition in which the stomach lining (mucosa) is inflamed.  Inflammation of your stomach lining causes an imbalance in the production of stomach acid and digestive enzymes.  This, in turn, causes poor digestion (not to mention all kinds of unpleasant stomach pain).  

Bile reflux is a condition in which bile, which belongs in the intestines, comes back (refluxes) into the stomach.  In severe cases, it can even reflex all the way into the esophagus (the tube connecting the stomach and the throat), causing irritation, pain, and inflammation.


Dyspepsia, commonly known as “indigestion” or “upset stomach”, is characterized by pain in the upper abdomen.   

Some of the specific symptoms of dyspepsia are:

  • upper abdominal fullness
  • heartburn
  • nausea
  • belching
  • persistent upper abdominal pain.

You may also find yourself feeling full earlier than expected when eating.  

Dyspepsia is a symptom of gallbladder disease that often fails to clear up after surgery.  


This is a condition that occurs when excess amounts of one compound of bile, bilirubin, builds up in your body.

Jaundice is diagnosed with high amounts of bilirubin in your blood.  

As long as your blood bilirubin levels are too high, you have jaundice.  But, typically, people don’t realize they have jaundice until they see it’s a tell-tale symptom in the mirror: a yellowing of the eyes, mouth, and (if jaundice becomes severe) skin.   

There are many causes of jaundice, but in the case of jaundice following gallbladder removal surgery the cause is typically an injury to the bile duct or leakage of the bile into the body.  

Are There Long-Term Risks of Not Having A Gallbladder?

Chopped broccoli and carrots on a cutting board

The symptoms of post-cholecystectomy syndrome don’t have to last long if you receive the right treatment.  However, if these digestive issues are allowed to persist, there is the chance that they might lead to more serious health conditions, such as:

Deficiencies in Fat-soluble Nutrients

As I talked about above, bile and bile acids are very important players in fat digestion and absorption.  Since healthy fat absorption is necessary for the normal absorption of fat-soluble vitamins, long-term poor bile balance can lead to deficiencies of these vitamins.  The fat-soluble vitamins that may be affected are vitamin A, D, K, and E.

Irritable Bowel Syndrome (IBS)

IBS is a condition that affects the large intestine.  It is characterized by a cluster of digestive symptoms (cramping, abdominal pain, and changes in the bowel movements) that last months or years.  

According to the existing literature, it is actually not completely clear whether gallbladder removal surgery increases the risk of IBS, or whether IBS is often inappropriately diagnosed as gallbladder disease, leading to unnecessary gallbladder surgeries.  One population-based study aimed to address this.

The researchers found that among patients that had undergone gallbladder removal surgery there was a two-fold risk of developing IBS, suggesting the surgery may, indeed, act as a trigger for IBS symptoms.  

Bile Acid Malabsorption

This condition (also known as “bile salt malabsorption”) is a dysfunction that describes the imbalance in bile salt circulation.  Normally, bile acids are (as you know) produced by the liver, stored in the gallbladder for a while, and then released into the small intestine.  After they do their job helping you absorb fat from your food, they are normally reabsorbed and returned to the liver.

If you have difficulty re-absorbing your bile acids (i.e. bile acid malabsorption), you end up with abnormally high levels of bile acids in your colon.  This keeps your colon from absorbing water properly, which, in turn, can lead to chronic, watery diarrhea (known as bile-salt-derived diarrhea).  

This condition may last just a few weeks after surgery, but it may persist in some cases for years, potentially causing problems with nutrient and water balance in your body!  

Can You Ease Digestive Symptoms After Gallbladder Removal?

Fresh salad with grilled chicken

As one of the members of the Academy of Nutrition and Dietetics’ Knowledge Center Team, points out, there is no standard guideline for easing digestive symptoms after gallbladder removal.  Each individual requires a personalized approach in order to obtain the best results.

However, there are a few dietary tips that everyone who’s undergone gallbladder removal surgery can follow to help minimize and resolve their symptoms.

These tips are:

Limit Fatty Foods

Foods rich in fat can be a bit heavy for people’s digestion even with normal bile release!  So, it’s no wonder that it can be particularly problematic after gallbladder removal surgery. 

Fatty foods that you want to avoid include:

To replace these high-fat foods in your diet, opt for:

Eat More Healthy Fats

Some vegetable oils tend to be problematic after invasive surgeries, like gallbladder removal, because they can promote inflammatory processes inside your body.  This can make recovery after surgery even more difficult.

Oils that may worsen inflammation in your body are those that are very rich in omega-6 fatty acids.  These oils include:

  • sunflower oil
  • safflower oil
  • corn oil
  • cottonseed oil
  • grapeseed oil
  • soybean oil

Note: store-bought products are made with these oils can also be problematic, such as mayonnaise and salad dressing.

To replace these oils in your diet, opt for oils rich in omega-3 fatty acids instead, such as extra virgin olive oil.

Eat Smaller Meals

Don’t overload your stomach and eat smaller portions.  Simpler and smaller meals are always easier for your stomach to digest and can reduce the number and severity of your digestive problems.

Increase Your Fiber Intake

Fiber is great for digestion because it aids bowel movements and protects your overall bowel health.  Epidemiological data suggest that it may even prevent you from developing gallstones in the first place.

Unfortunately, some types of fiber can trigger gas, cramps, or bloating for some people.  So, while you should definitely include fiber-rich foods in your diet, it’s a good idea to start with smaller quantities to avoid potentially making your digestive symptoms worse.

Foods rich in fiber you should work into your diet gradually include:

  • cabbage
  • broccoli
  • Brussel sprouts
  • beans
  • legumes

Avoid Foods That May Irritate Your Stomach

If you suffer from reflux, avoid these foods and beverages that may irritate your stomach:

  • alcohol
  • caffeinated and carbonated drinks
  • chocolate
  • citrus foods and juices
  • coffee
  • vinegar-based dressings
  • onions
  • tomato-based foods
  • spicy foods
  • mint

Avoid Foods That May Promote Bloating

If you face bloating issues more often than reflux and dyspepsia, check out this guide on foods to avoid and to bone up on in order to reduce bloating!

Boost Digestion with Enzymes

Although there is no direct evidence that recommends digestive enzyme therapy to ease digestive disorders after gallbladder removal, there is ample data that suggests that these supplements may be helpful in reducing some of the gastrointestinal symptoms associated with the surgery.  

For instance:

  • supplements containing all digestive enzymes (amylases, proteases, and lipases) have been proven effective in relieving dyspeptic symptoms  
  • lipases have been shown to improve the symptoms of diarrhea-dominant IBS (including cramping, bloating, frequent and urgent defecation) in at least one pilot study of 49 patients  
  • complete pancreatic digestive enzymes are the preferred treatment for steatorrhea — diarrhea caused by poor fat absorption.

The combination of available evidence suggests that if you are struggling with chronic digestive symptoms after gallbladder removal, digestive enzymes may offer you some relief.

What Are Digestive Enzymes?

Womans hand holding digestive enzyme supplements

Digestive enzymes are protein compounds that have a very specific function within your body — to help you better digest and absorb the foods you consume. 

They do this by adding molecules of water into the structure of your food and breaking down the chemical bonds present within complex food molecules.

By doing this, they actually break up the complex molecules into smaller building blocks, which your body can absorb and use.

These enzymes specifically work by breaking:

  • proteins into amino acids (done by a group of enzymes called “proteases”)
  • carbohydrates into sugars (done by a group of enzymes known as “amylases”)
  • fats into fatty acids (done by a group of enzymes called “lipases”)

Your body naturally makes these enzymes and uses them as part of the digestion process. 

You also get lots of digestive enzymes naturally through your diet.  There are many foods rich in digestive enzymes, such as pineapple, oats, and papaya.  

However, when we’re talking about specific digestion problems after gallbladder removal, you may want to opt for digestive enzymes in the form of supplements!  

Digestive enzyme supplements contain higher doses of very specific digestive enzymes that will likely make it easier to target your symptoms, specifically, and start seeing results.

Related Reading: Top 5 Best Digestive Enzyme Supplements to Fix Leaky Gut

Do Digestive Enzymes Have Any Side Effects?

Pregnant woman standing in the sunshine

For most people, digestive enzymes are quite safe.  

And when we talk about safety, I am specifically referring to the supplemental, not the food form of digestive enzymes.  

(If you are not allergic to that specific food, it is completely safe to consume digestive enzymes as part of your diet).  

There are a few small exceptions to this rule, however.  These are if you:

  • take warfarin (or another blood-thinning medication).  A specific enzyme, bromelain (a protease), may lead to enhanced bleeding if you take it with certain blood thinners. Bromelain possesses anti-clotting properties, so you may want to avoid it during menstrual periods, as well, because it can lead to excess bleeding.
  • are allergic to ingredients used in the preparation of the supplement.  Pay attention to the ingredients used for the production of digestive enzymes.  If you are allergic to some of the foods used for the extraction of the enzymes, or to some other compounds used in the production of the supplement, you may be at risk for an allergic reaction.
  • are pregnant.  There is not much evidence about the possible effects of digestive enzymes on women or babies during pregnancy.  Until we have more data, it’s better to be on the safe side and avoid them completely.

If aren’t on warfarin, allergic to any ingredients, or pregnant, it is likely completely safe to give a digestive enzyme supplement a try.

Just take care to follow the recommended doses.

Best Digestive Enzymes After Gallbladder Removal

Disclosure – This post contains affiliate links.  Click here for details.

Unfortunately, if you search the scientific literature for the best digestive enzymes for easing digestion issues after gallbladder removal, no studies come up.  

To the best of our knowledge, no clinical trials have been done on this topic at all. 

Nevertheless, I looked at the clinical trial evidence from related conditions (IBS, dyspepsia, fat malabsorption, pancreatic insufficiency, etc.).  I also looked into the manufacturer’s guidelines, and the personal experiences people have shared online. 

Using the information I found, I put together a list of five supplements that are likely to help ease digestive symptoms after gallbladder removal surgery.

Here are my picks!

5. Dr. Mercola Gallbladder Enzymes

Dr. Mercola Gallbladder EnzymesAmazon Button

This product has an average rating of 3.1 stars on Amazon.  

It is an animal-based (head’s up vegetarians and vegans!) that’s been coated to prolong the enzymatic activity in your digestive tract.

Each capsule contains ox bile, pancrelipase (pancreatic protease, amylase, and lipase), and adenosine triphosphate (ATP) that work together to ease intestinal discomfort and facilitate healthy digestion.  

The producers recommend it to those on a gallbladder treatment diet and those who have had their gallbladders removed.

4. Sunfood Superfoods Digestive Enzymes

Sunfood Digestive Enzymes

Amazon Button

This supplement is not specifically made for treating gallbladder problems but people report it being very useful for supporting digestion after gallbladder removal.  Fifteen people have ranked this product with an average of 4 stars on Amazon.

It is plant-based (read vegan and vegetarian-friendly!) and contains a mixture of amylases, protease, and lipases.

3. Renew Life Adult Digestive Enzyme

Renew Life Digest Smart Digestive EnzymesAmazon Button This supplement has a 4-star ranking on Amazon.  

Although not clearly stated in the product name, personal anecdotes online report this supplement really helped them after gallbladder operation.  

Renew Life Adult Digestive Enzyme contains a blend of all three digestive enzyme types and some additional digestion-promoting ingredients.  

Importantly, this supplement is made from plant sources, which means that will be more resistant in the acidic environment in your stomach and it is suitable for vegetarians and vegans.

2. Lion Heart Enzyme +7 Supplement

Lion Heart Enzyme +7 Amazon Button

This is one of the digestive enzyme supplements which customers recommend after taking it specifically after gallbladders removal surgery.  The majority (83%) of them gave it a 5-star rating.

This supplement is a mixture of all three types of digestive enzymes, plus it contains additional bile salts that should aid fat absorption.  

This mixture should boost your body’s ability to digest fats, fiber, protein, and carbs as well as cellulose and gluten and, hopefully, seriously improve your digestive health.

1. BULK POWDERS Pure DigeZyme

BULK Powders DigeZyme

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Though it doesn’t have a lot of reviews on Amazon, the wider public reviewed this product on other websites to acclaim.  It is, again, a plant-based product and it contains amylases, lactases, cellulases, proteases, and lipases.

It is also the only product on our list that passed clinical testing!  The clinical trial looked at 40 patients suffering from functional dyspepsia, in a randomized, placebo-controlled trial. 

The researchers concluded that 50 mg of this supplement for 60 days eased all dyspepsia symptoms without any side effects.

So, while not specifically tested on those who’ve had their gallbladder removed, there is a good reason to suspect that if your gallbladder surgery is causing chronic indigestion, this supplement may be worth a try!

As you may have noticed, all the supplements above contain similar compounds, just in different ratios.  

It’s up to you to investigate and figure out which one is the best fit for you and your symptoms! 

It’s always the best to consult with the doctor and get a precise clinical and lab evaluation before starting any new supplements.

Take Home Message

The rate of gallbladder disease has been showing a steady increase year after year.  

If you want to make sure you don’t contribute to that statistic in the future, think about your lifestyle habits now.  Change the bad ones and boost the good!

It may happen that, despite your best efforts, you do end up needing your gallbladder removed and continue experiencing digestive difficulties afterward.

In that case, take your health into your hands to relieve or eliminate the symptoms!  

And it actually may not be that hard.  Just be disciplined in applying the necessary diet modifications and support the healing process with adequate digestive enzyme supplements!

Supplementing with butyrate may help your gut wall get stronger, healthier, and more able to do its job. Read Next: Top 5 Best Butyrate Supplements for Leaky Gut Cure



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